Investigators Meeting 2010
Date: 25 February, 2010
Venue: The Westin Miyako Hotel Kyoto
The OOTR Investigator's Meeting was held in the Hoo-no-ma room, 4th Floor, Westin Miyako Hotel, Kyoto on 25th February 2010. Professor Louis Chow, Honorary Clinical Professor of the University of Hong Kong and Executive Director of OOTR, welcomed the investigators who had traveled to Kyoto from various countries. All participants of the meeting then gave a self-introduction.
Prof Chow gave an update on OOTR-N001 stating that recruitment had stopped in December 2009. 64 patients had been recruited in total with 54 from Hong Kong, 8 from Korea and 1 from mainland China. Dr TJ Yao of the Clinical Trials Centre, The University of Hong Kong gave a brief overview on biomarkers and pathological assessment. Professor Sasano of Tohoku University said that a central analysis would be necessary. Sample collection for central review in Korea and Hong Kong were judged to be OK.
Dr Shinji Ohno of the National Kyushu Cancer Center, Fukuoka, Japan said that for OOTR-N003, 500 patients had been enrolled as of last August, with 110 from Niigata Cancer Center. CRFs should be collected within a few months. As for side-effect data, more information was necessary.
Dr Takayuki Ueno of Kyoto University Hospital, Kyoto, Japan said of OOTR-N003 that a central review of pathological response and residual tumor burden was needed. All participants agreed on the importance of both assessments. Regarding materials: All but one institute (Prof Chow) preferred slides to blocks. All participants (institutes) considered both pre-treatment and post-treatment tissue samples were important and available for translational research.
All institutes expressed an interest in the following proposals: High sensitivity CTC, Blood DNA, mRNA, monitoring after PST and 3 and 5 years after surgery, to conduct a genome-wide association study for therapeutic effect and adverse events.
Professor Masakazu Toi of Kyoto University Hospital, Kyoto, Japan, outlined some new proposals regarding ICG fluorescence and radioisotope methods for SLNB. Then Dr. Nakamura of St Luke’s International Hospital, Chiba University, Tokyo, Japan gave 2 lectures: one on the present status of sentinel lymph-node and another on updated guidelines. The meeting was then ended.